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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">2691</journal-id>
      <journal-title-group>
        <journal-title>Delirium Communications</journal-title>
        <abbrev-journal-title>Delirium Communications</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="epub">2959-104X</issn>
      <publisher>
        <publisher-name>European Delirium Association</publisher-name>
      </publisher>
      <self-uri xlink:href="https://deliriumjournal.com/">Website: Delirium</self-uri>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">92219</article-id>
      <article-id pub-id-type="doi">10.56392/001c.92219</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Articles</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Delirium is Under-Detected on Routine Screening with the CAM: a Sub-Study from World Delirium Awareness Day</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name>
            <surname>Byrnes</surname>
            <given-names>Tru</given-names>
          </name>
          <xref ref-type="corresp" rid="author-note-1"/>
          <xref ref-type="aff" rid="author-aff-1">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Gombar</surname>
            <given-names>Meridith</given-names>
          </name>
          <xref ref-type="aff" rid="author-aff-2">
            <sup>2</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Price</surname>
            <given-names>Sarah</given-names>
          </name>
          <xref ref-type="aff" rid="author-aff-1">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Cochran</surname>
            <given-names>Allyson</given-names>
          </name>
          <xref ref-type="aff" rid="author-aff-3">
            <sup>3</sup>
          </xref>
          <xref ref-type="aff" rid="author-aff-4">
            <sup>4</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Love</surname>
            <given-names>Karrie</given-names>
          </name>
          <xref ref-type="aff" rid="author-aff-1">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Gregory</surname>
            <given-names>Amanda</given-names>
          </name>
          <xref ref-type="aff" rid="author-aff-1">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Rankin</surname>
            <given-names>Veronica</given-names>
          </name>
          <xref ref-type="aff" rid="author-aff-1">
            <sup>1</sup>
          </xref>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Daye-Whitehead</surname>
            <given-names>Katrina</given-names>
          </name>
          <xref ref-type="aff" rid="author-aff-1">
            <sup>1</sup>
          </xref>
        </contrib>
      </contrib-group>
      <aff id="author-aff-1">
        <label>1</label>
        <institution-wrap>
          <institution content-type="dept">Nursing</institution>
        </institution-wrap>
        <institution-wrap>
          <institution content-type="edu">Carolinas Medical Center</institution>
        </institution-wrap>
        <institution-wrap>
          <institution-id institution-id-type="ROR">https://ror.org/0483mr804</institution-id>
        </institution-wrap>
      </aff>
      <aff id="author-aff-2">
        <label>2</label>
        <institution-wrap>
          <institution content-type="dept">Nursing</institution>
        </institution-wrap>
        <institution-wrap>
          <institution content-type="edu">Atrium Health Mercy</institution>
        </institution-wrap>
      </aff>
      <aff id="author-aff-3">
        <label>3</label>
        <institution-wrap>
          <institution content-type="dept">Carolinas Center for Surgical Outcomes Science</institution>
        </institution-wrap>
        <institution-wrap>
          <institution content-type="edu">Atrium Health-Carolinas Medical Center</institution>
        </institution-wrap>
      </aff>
      <aff id="author-aff-4">
        <label>4</label>
        <institution-wrap>
          <institution content-type="dept">Wake Forest University School of Medicine</institution>
        </institution-wrap>
        <institution-wrap>
          <institution content-type="edu">Atrium Health</institution>
        </institution-wrap>
      </aff>
      <author-notes>
        <corresp id="author-note-1"><bold>Corresponding Author:</bold> Tru Byrnes, DNP, RN 1000 Blythe Blvd Charlotte, NC 28203 Tru.byrnes@atriumhealth.org</corresp>
      </author-notes>
      <pub-date publication-format="electronic" date-type="pub" iso-8601-date="2024-02-05">
        <day>5</day>
        <month>2</month>
        <year>2024</year>
      </pub-date>
      <elocation-id>92219</elocation-id>
      <history>
        <date date-type="received" iso-8601-date="2023-11-20">
          <day>20</day>
          <month>11</month>
          <year>2023</year>
        </date>
        <date date-type="accepted" iso-8601-date="2024-01-12">
          <day>12</day>
          <month>1</month>
          <year>2024</year>
        </date>
      </history>
      <permissions>
        <license license-type="open-access">
          <ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
              http://creativecommons.org/licenses/by/4.0
            </ali:license_ref>
          <license-p>
              This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">Creative Commons Attribution License (4.0)</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
            </license-p>
        </license>
      </permissions>
      <self-uri content-type="pdf" xlink:href="https://deliriumjournal.com/article/92219.pdf"/>
      <self-uri content-type="xml" xlink:href="https://deliriumjournal.com/article/92219.xml"/>
      <self-uri content-type="json" xlink:href="https://deliriumjournal.com/article/92219.json"/>
      <self-uri content-type="html" xlink:href="https://deliriumjournal.com/article/92219"/>
      <abstract>
        <sec>
          <title>Background</title>
          <p>Delirium is an acute change in mental status that affects more than 2.6 million hospitalised adults annually. Patients who experience delirium suffer extended hospital stays and increased mortality and morbidity. Delirium screening is fundamental in driving prevention and early detection. This project aimed to examine delirium assessment, recognition for patients over 18, barriers to implementing delirium prevention treatment, and report qualitative findings for delirium care.</p>
        </sec>
        <sec>
          <title>Method</title>
          <p>In mid-March 2023, 11 Clinical Nurse Leaders in the Southeast Region of the United States participated in a study to increase awareness of delirium called World Delirium Awareness Day. Data was collected using an online survey to assess unit census, the number of CAM assessments, and positive CAM screening at 8:00 A.M (+/- 4 hrs) and 8:00 PM (+/- 4 hrs). Patients were defined as having delirium if their electronic healthcare record documentation reflected at least one occurrence of a positive CAM score. The survey comprised 39 “select all that apply” questions and three open-ended questions.</p>
        </sec>
        <sec>
          <title>Results</title>
          <p>Results show 418 (64%) CAM assessments were completed. Greater compliance was found during the morning assessment than the evening shift. Differences in nursing practice and opinions were also identified between General and High Acuity Units. Among patients receiving assessments, delirium recognition was 2% (8:00 A.M.) and 3% (8:00 P.M.). There was a significant difference in the use of multi-professional daily goals between the two unit types as a non-pharmacologic intervention for delirium (General: 0% vs. High Acuity: 100%, p=.003). Barriers identified: shortage of personnel, interprofessional communication gaps, and difficult-to-assess patients. Recommendations for delirium care include staff education and implementing an EHR tool to remind nurses to assess and document delirium.</p>
        </sec>
        <sec>
          <title>Conclusion</title>
          <p>Findings from this study reveal the need for staff education, support, and the enhancement of resources to promote delirium prevention.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>Delirium</kwd>
        <kwd>Nursing Assessment</kwd>
        <kwd>Confusion</kwd>
        <kwd>Recognition</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec>
      <title>INTRODUCTION</title>
      <p>Delirium is an acute, and often preventable medical condition characterised by acute onset, fluctuation, inattention, disorganised thinking, and altered level of consciousness.<xref ref-type="bibr" rid="ref-273592"><sup>1</sup></xref> Delirium affects more than 2.6 million hospitalised adults annually in the United States (US).<xref ref-type="bibr" rid="ref-273592"><sup>1</sup></xref> Despite its high prevalence, up to 60% of the time, delirium is under-recognised by healthcare professionals.<xref ref-type="bibr" rid="ref-273593"><sup>2</sup></xref> Under-recognition can negatively impact patient outcomes, such as increased mortality, morbidity, and financial cost. Patients may require an extended hospitalisation, up to 5-10 days.<xref ref-type="bibr" rid="ref-273592"><sup>1</sup></xref> This extended length of stay contributes to higher inpatient healthcare costs of $81 billion annually.<xref ref-type="bibr" rid="ref-273594"><sup>3</sup></xref> The mortality risk of patients with delirium increases up to 3-fold the year following diagnosis compared to patients without delirium.<xref ref-type="bibr" rid="ref-273595"><sup>4</sup></xref></p>
      <p>Kim and colleagues<xref ref-type="bibr" rid="ref-273596"><sup>5</sup></xref> recognised assessment as essential in delirium management, driving prevention and early detection. The Confusion Assessment Method (CAM) tool and its adapted versions are commonly used due to their high sensitivity and specificity when used with a structured formal cognitive assessment.<xref ref-type="bibr" rid="ref-273597"><sup>6</sup></xref> Continued research recognises that appropriate use of the CAM does require specific training, and operationalisation of the tool can be subjectively affected by nursing experience and attitudes,<xref ref-type="bibr" rid="ref-273598"><sup>7</sup></xref> suggesting facilities already using the CAM may need to evaluate the current state of nursing education and the efficacy of its use. Lack of time, staffing, and interprofessional collaboration make routine delirium assessment and implementing delirium management methods difficult, regardless of the screening tool being used.<xref ref-type="bibr" rid="ref-273599"><sup>8</sup></xref></p>
      <p>The COVID-19 pandemic has exacerbated these existing challenges. Obregon-Gutierrez and colleagues<xref ref-type="bibr" rid="ref-273600"><sup>9</sup></xref> recognised that care left undone was a fundamental consequence of the pandemic, causing care to be highly prioritised where essential, with psychosocial and time-consuming activities all receiving lower priority. Delirium has not been accurately prioritised in recent years, despite evidence suggesting an increase in prevalence and mortality, particularly amongst the COVID-19 population.<xref ref-type="bibr" rid="ref-273601 ref-273602"><sup>10,11</sup></xref> As such, limited literature examines delirium assessment and the use of evidence-based interventions to mitigate delirium post-pandemic. To address this knowledge gap, the Delirium Point Prevalence Survey was conducted on World Delirium Awareness Day (WDAD), March 15, 2023, to assess worldwide delirium prevalence, structures, processes, and barriers to implementing interventions to mitigate delirium. Forty-four countries and 1,664 units participated in the WDAD study, two of which were our facilities. To better understand the delirium practice and for future quality improvement, we performed a sub-analysis for our two hospitals. Thus, the primary aim was to assess delirium assessment and recognition for patients aged 18 and over among acute care nurses. The secondary aim was to summarise delirium-related protocols, pharmacological and non-pharmacological interventions, and barriers to implementing delirium prevention and treatment, and report qualitative findings of delirium care.</p>
    </sec>
    <sec>
      <title>METHOD</title>
      <sec>
        <title>Design and Setting</title>
        <p>This is a sub-analysis of a prospective, international prevalence survey conducted on WDAD, an annual international day to increase awareness of delirium amongst healthcare professionals, patients, and caregivers.<xref ref-type="bibr" rid="ref-273603"><sup>12</sup></xref> Fourteen units at two hospitals: a 652-bed Level-1 tertiary research and academic medical centre and a 207-bed community hospital participated in the WDAD Prevalence Study. Of 11 General Units, seven belong to the community hospital; 4 remaining were from the tertiary hospital. Two High Acuity Units were from a community hospital, and 1 was from a tertiary hospital. General units include medical-surgical, neurology, and orthopedic units, whereas High Acuity Units include step-down and intensive care units (ICU). Approval was received from the Advocate Health Wake Forest University Institutional Review Board (Protocol # IRB00092271).</p>
      </sec>
      <sec>
        <title>Participants and Data Collection</title>
        <p>Twenty Clinical Nurse Leaders (CNL) from all specialties at two hospitals were invited to complete a web-based survey during the WDAD; 11 (55%) completed the survey. The WDAD Prevalence survey contains 39 “select all that apply” questions assessing the characteristics of respondents, hospitals, units, structures, delirium prevention and management processes, and barriers to implementing delirium evidence-based strategies (Online Supplemental Table 1). In addition, three open-ended questions asked for recommendations for delirium care and future research. To answer the survey questions, these CNLs must have reviewed the unit census and electronic healthcare record (EHR) of patients aged 18 and older at 8 A.M (+/-4hrs) and 8 P.M (+/-4 hrs) on March 15, 2023, to identify the number of patients on the unit, the number of CAM assessments, and positive CAM screening. A patient was defined as having delirium if their EHR documentation reflected at least one occurrence of a positive CAM. All surveys had to be returned to the study team by March 17, 2023, or were excluded. Permission was granted from the international study team to perform this sub-analysis.</p>
      </sec>
      <sec>
        <title>Statistical Methods</title>
        <p>Categorical survey data were reported as numbers and percentages. Comparative analysis between the two-unit groups (General and High Acuity) was performed using Fisher’s exact test. Continuous data associated with delirium assessments were assessed for normality, and either an unequal sample t-test or Wilcoxon rank-sum test was performed as appropriate to the data. Means and standard deviations were reported. Radar graphs were generated to visualise the <italic>Non-pharmacological treatment</italic> and <italic>Barriers against implementation</italic> data.</p>
        <p>Data for the variables for <italic>Non-pharmacological prevention and treatment</italic>, <italic>Pharmacological treatment</italic>, and <italic>Barriers against implementation and/or use of evidence-based strategies are</italic>… were assessed and grouped by the variable designating unit type. Percentages were created where the denominator was the number of patients present in their respective units at the AM and PM times indicated on the survey, and the numerators were patients assessed positive by CAM; creating four variable types: AM Patients Assessed Percentage, PM Patients Assessed Percentage, AM Patients Positive Percentage, and PM Patients Positive Percentage. All data were analysed by Stata 17 (College Station, TX: StataCorp LLC) and p&lt;.05 was considered statistically significant.</p>
      </sec>
    </sec>
    <sec>
      <title>Results</title>
      <sec>
        <title>Patient Assessments</title>
        <p>For the tertiary hospital, 137 patients were present on the unit at 8 A.M, 70 (51%) CAM assessments were documented. At 8 P.M of 137 patients, 64 (47%) CAM assessments were performed. At the community hospital, of the 191 patients on the unit at 8 A.M, 154 (81%) CAM assessments were documented, and at 8 P.M, 168 patients were present on the unit, 130 (77%) CAM assessments were documented. Among CAM assessments, positive CAM screening was 2% and 3% (5 CAM assessments at 8:00 A.M. and 8:00 P.M.), respectively. The overall average number of patients assessed for delirium was higher in the morning (AM: 17.5 vs. PM: 14.5), though when stratified by unit type, this pattern was not found in the High Acuity Unit (AM: 10.7 vs. PM: 11.3). There were no significant differences between the unit types in percentage of patients either assessed for, or positive for delirium in either AM or PM (<xref ref-type="table" rid="attachment-192238">Table 1</xref>). However, while not significant at a p&lt;.05 level, the average AM percentage of patients positive for delirium in the General Units trended towards a much lower than average AM percentage of patients positive in the High Acuity Units (General: 0.35% vs. High Acuity: 7.4%, p=.066).</p>
        <table-wrap id="attachment-192238">
          <object-id pub-id-type="publisher-id">192238</object-id>
          <label>Table 1.</label>
          <caption>
            <title>Delirium assessments</title>
          </caption>
          <table>
            <tbody>
              <tr>
                <td>Variable</td>
                <td>General Unit<break/>n=11</td>
                <td>High Acuity Unit<break/>n=3</td>
                <td>p-value</td>
              </tr>
              <tr>
                <td>AM Patient Count<sup>a</sup>
</td>
                <td>25 (7.6)</td>
                <td>17.7 (0.6)</td>
                <td>.010*</td>
              </tr>
              <tr>
                <td>AM Patients Assessed for Delirium<sup>a</sup>
</td>
                <td>17.5 (7.7)</td>
                <td>10.7 (4.5)</td>
                <td>.102</td>
              </tr>
              <tr>
                <td>AM Patients Assessed Percentage<sup>a</sup>
</td>
                <td>70.2 (0.2)</td>
                <td>59.9 (0.2)</td>
                <td>.553</td>
              </tr>
              <tr>
                <td>AM Patients Positive Percentage<sup>b</sup>
</td>
                <td>0.35 (1.1)</td>
                <td>7.4 (8.5)</td>
                <td>.066</td>
              </tr>
              <tr>
                <td> </td>
                <td/>
                <td/>
                <td/>
              </tr>
              <tr>
                <td>PM Patient Count<sup>a</sup>
</td>
                <td>23.1 (8.5)</td>
                <td>17 (2.6)</td>
                <td>.065</td>
              </tr>
              <tr>
                <td>PM Patients Assessed for Delirium<sup>a</sup>
</td>
                <td>14.5 (5.3)</td>
                <td>11.3 (4.2)</td>
                <td>.328</td>
              </tr>
              <tr>
                <td>PM Patients Assessed Percentage<sup>a</sup>
</td>
                <td>68.2 (0.3)</td>
                <td>65.6 (0.2)</td>
                <td>.842</td>
              </tr>
              <tr>
                <td>PM Patients Positive Percentage<sup>b</sup>
</td>
                <td>1.9 (3.7)</td>
                <td>1.8 (3.0)</td>
                <td>.846</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <p>Numbers reported as mean (SD)</p>
            <p><sup>a</sup>t-test of unequal variances</p>
            <p><sup>b</sup>Wilcoxon rank-sum</p>
            <p>* Significance at p&lt;.05</p>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Interventions</title>
        <p>There was a significant difference in the use of multiprofessional daily goals between the two-unit types as a non-pharmacologic intervention for delirium (General: 0% vs. High Acuity: 100%, p=.003) (Online Supplemental Table 2). The General Units reported family information, mobilisation, pain management, avoidance of catheters, family engagement, adequate fluids, and verbal re-orientation at frequencies greater than 90%. The High Acuity Units also reported mobilisation, pain management, adequate fluids, and verbal re-orientation at high frequencies; however, the difference from the General Unit was they also reported open visiting times, cognitive stimulation, ear plugs, and multiprofessional daily goals at high-frequency utilisation (<xref ref-type="fig" rid="attachment-192241">Figure 1</xref>). As for pharmacologic interventions, there were no significant differences between the two unit types (<xref ref-type="table" rid="attachment-192239">Table 2</xref>).</p>
        <fig id="attachment-192241">
          <object-id pub-id-type="publisher-id">192241</object-id>
          <label>Figure 1.</label>
          <caption>
            <title>Radio Graph displays type of Non-Pharmacological Interventions</title>
          </caption>
          <graphic xlink:href="assets/delirium_2024_92219_192241.png"/>
        </fig>
        <table-wrap id="attachment-192239">
          <object-id pub-id-type="publisher-id">192239</object-id>
          <label>Table 2.</label>
          <caption>
            <title>Pharmacologic Interventions by Unit Type</title>
          </caption>
          <table>
            <tbody>
              <tr>
                <td>Intervention</td>
                <td>General Unit<break/>n=11</td>
                <td>High Acuity Unit<break/>n=3</td>
                <td>p-value</td>
              </tr>
              <tr>
                <td>Haloperidol</td>
                <td>4 (36.4)</td>
                <td>1 (33.3)</td>
                <td>.923</td>
              </tr>
              <tr>
                <td>Risperidone</td>
                <td>2 (18.2)</td>
                <td>1 (33.3)</td>
                <td>.571</td>
              </tr>
              <tr>
                <td>Lorazepam</td>
                <td>3 (27.3)</td>
                <td>1 (33.3)</td>
                <td>.837</td>
              </tr>
              <tr>
                <td>Quetiapine</td>
                <td>3 (27.3)</td>
                <td>1 (33.3)</td>
                <td>.837</td>
              </tr>
              <tr>
                <td>Melatonin</td>
                <td>3 (27.3)</td>
                <td>1 (33.3)</td>
                <td>.837</td>
              </tr>
              <tr>
                <td>Reduction of potentially delirogenous drugs</td>
                <td>4 (36.4)</td>
                <td>1 (33.3)</td>
                <td>.923</td>
              </tr>
              <tr>
                <td>Evaluation of drugs by a specialist</td>
                <td>4 (36.4)</td>
                <td>1 (33.3)</td>
                <td>.923</td>
              </tr>
              <tr>
                <td>Do not know</td>
                <td>3 (27.3)</td>
                <td>0</td>
                <td>.308</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <p>Numbers reported as n (%)</p>
            <p>Fisher’s exact Chi-square</p>
            <p>* Significance at p&lt;.05</p>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Barriers</title>
        <p>The High Acuity Units reported “Patients who are difficult for assessment” as a barrier significantly more than the General Units (General: 9.1% vs. High Acuity: 100%, p=.011) (<xref ref-type="table" rid="attachment-192240">Table 3</xref>). The General Units reported a lack of knowledge about delirium and a lack of awareness in frequencies above 90%, and the High Acuity Units also reported these barriers in high frequency, with the addition of shortage of personnel, communication gaps between professionals, and patients who are difficult to assess (<xref ref-type="fig" rid="attachment-192241">Figure 1</xref>).</p>
        <table-wrap id="attachment-192240">
          <object-id pub-id-type="publisher-id">192240</object-id>
          <label>Table 3.</label>
          <caption>
            <title>Barriers by Unit Type</title>
          </caption>
          <table>
            <tbody>
              <tr>
                <td>Barriers</td>
                <td>General Unit<break/>n=11</td>
                <td>High Acuity Unit<break/>n=3</td>
                <td>p-value</td>
              </tr>
              <tr>
                <td>Lack of time to educate and train staff</td>
                <td>3 (27.3)</td>
                <td>2 (66.7)</td>
                <td>.505</td>
              </tr>
              <tr>
                <td>Lack of awareness</td>
                <td>10 (90.9)</td>
                <td>3 (100)</td>
                <td>.588</td>
              </tr>
              <tr>
                <td>Shortage of personnel/staff</td>
                <td>8 (72.7)</td>
                <td>3 (100)</td>
                <td>.308</td>
              </tr>
              <tr>
                <td>No cost/resources for promoting at the department</td>
                <td>1 (9.1)</td>
                <td>1 (33.3)</td>
                <td>.396</td>
              </tr>
              <tr>
                <td>Lack knowledge about delirium</td>
                <td>11 (100)</td>
                <td>3 (100)</td>
                <td>--</td>
              </tr>
              <tr>
                <td>Communication gaps between professionals</td>
                <td>8 (72.7)</td>
                <td>3 (100)</td>
                <td>.308</td>
              </tr>
              <tr>
                <td>Delirium is not important attitude</td>
                <td>5 (45.5)</td>
                <td>2 (66.7)</td>
                <td>.515</td>
              </tr>
              <tr>
                <td>Lack of motivated staff</td>
                <td>6 (54.6)</td>
                <td>2 (66.7)</td>
                <td>.707</td>
              </tr>
              <tr>
                <td>Leadership does not support</td>
                <td>2 (18.2)</td>
                <td>0</td>
                <td>.425</td>
              </tr>
              <tr>
                <td>Lack of non-pharmacological interventions</td>
                <td>2 (18.2)</td>
                <td>2 (66.7)</td>
                <td>.176</td>
              </tr>
              <tr>
                <td>Lack of pharmacological interventions</td>
                <td>0</td>
                <td>1 (33.3)</td>
                <td>.214</td>
              </tr>
              <tr>
                <td>No appropriate scores for assessment of delirium</td>
                <td>6 (54.6)</td>
                <td>2 (66.7)</td>
                <td>.707</td>
              </tr>
              <tr>
                <td>Patients who are difficult for assessment</td>
                <td>1 (9.1)</td>
                <td>3 (100)</td>
                <td>.011*</td>
              </tr>
              <tr>
                <td>Inter-professional conflicts</td>
                <td>0</td>
                <td>1 (33.3)</td>
                <td>.214</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <p>Numbers reported as n (%)</p>
            <p>Fisher’s exact Chi-square</p>
            <p>* Significance at p&lt;.05</p>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Qualitative findings: Recommendations for delirium care</title>
        <p>The survey respondents recommended frequent delirium education, focusing on how to use the CAM tool to increase accuracy. One respondent wrote, <italic>staff needs more education on CAM scores. Current scoring may not be appropriate/accurate</italic>. Additionally, non-pharmacological interventions such as providing vision and hearing aids, day and nighttime rhythm, multidisciplinary rounds, and patient education are essential in preventing and managing delirium. However, as shown in <xref ref-type="fig" rid="attachment-192241">Figure 1</xref>, these interventions are seldom being provided, which may be due to a lack of time and resources. A participant wrote, <italic>non-pharmacological interventions can be effective but can take more time. Most units are also not stocked with activities for patient</italic>s. Participants also suggested leveraging the EHR to increase delirium assessment by <italic>linking the delirium assessment admission checklist, or shift required actions; otherwise, CAM is not assessed regularly</italic>. Based on the participant’s perspective, integrating this simple reminder will help nurses remember to assess and document delirium in the EHR. Overall, the survey respondents expressed motivation to do the right thing for their patients, <italic>as a healthcare provider, I am motivated to promote awareness and education</italic> of delirium. However, staff will need support such as enhancing EHR tools, access to delirium prevention supplies, receive continuing delirium education, and ensure adequate staffing.</p>
      </sec>
    </sec>
    <sec>
      <title>DISCUSSION</title>
      <p>Results revealed that for the two hospitals, delirium assessment compliance was higher in the mornings than at night. This may indicate a need for education and auditing with real-time feedback to promote practice change for night shift nurses. Understandably, the goal is to avoid waking patients to assess them for delirium; however, with appropriate planning, delirium assessment can be performed near the beginning of the shift before bedtime.</p>
      <p>The General Units identified a lower percentage of positive CAM assessments than the High Acuity Units. This finding could be related to the need for staff training to ensure that the assessment and documentation are done correctly for follow-up purposes. Education should include the current assessment compliance rates and the devastating effects of delirium. Identifying the <italic>why</italic> behind this potentially life-saving assessment could positively impact practice change. Additionally, staffing resources could positively impact assessment compliance.</p>
      <p>The High Acuity Units used more non-pharmacological interventions than the General Units, such as open visiting times, cognitive stimulation, ear plugs, and multi-professional daily goals. This finding suggests the need for more resources such as interprofessional collaboration, ear plugs, and tools for cognitive stimulation, education, hands-on demonstration, and training for staff in the General Units. Visitation hours are usually an issue only in ICU areas, which may explain why this non-pharmacological intervention is not often documented in General Units.</p>
      <p>While the General Units and the High Acuity Units did not differ significantly in their use of pharmacological interventions, both units noted a lack of knowledge and awareness of delirium. Furthermore, the High Acuity Units also reported staff shortages, communication gaps between the interprofessional team, and a higher percentage of patients who are difficult to assess. Staffing shortages are a chronic problem in any healthcare facility. Thus, nurse leaders should consider strategies such as implementing telehealth nurses, incorporating behavioural health navigators, and brainstorming other ideas to help lighten the load on frontline nurses and give time back to nurses to perform critical assessments of their patients. Additional recommendations include enhancing EHR tools with hard stops that require the documentation of delirium assessment and creating policies requiring delirium assessment and documentation as part of the nursing process.</p>
      <p>Other studies have shown that delirium is often missed in clinical care, as high as 75% of the time.<xref ref-type="bibr" rid="ref-273604 ref-273605"><sup>13,14</sup></xref> Acknowledging this fact, the authors approached this project through the lens of delirium assessment compliance instead of point prevalence. As expected, the overall positive CAM screening was low amongst nurses across all specialties compared to previous studies (2-3% vs. 23 - 32%).<xref ref-type="bibr" rid="ref-273603 ref-273606"><sup>12,15</sup></xref> Increased screening rates were typically associated with increased recognition.<xref ref-type="bibr" rid="ref-273603"><sup>12</sup></xref> However, this was not the case with this project. The overall average of delirium screening performed was 64% for this study, much higher than Geriatric Medicine Research study of 24%.<xref ref-type="bibr" rid="ref-273603"><sup>12</sup></xref> Therefore, when evaluating the delirium recognition rate, researchers must consider other factors, such as the clinician’s knowledge and whether they understand how to use the delirium screening tool appropriately. Researchers should also constantly assess the clinical tools that are part of their standard operating procedure. With the CAM tool’s known low sensitivity and implementation difficulties, hospitals should investigate the possibility of more pragmatic tools to detect delirium, such as the 4AT.<xref ref-type="bibr" rid="ref-273607"><sup>16</sup></xref></p>
      <sec>
        <title>Limitations</title>
        <p>Several limitations to this study prevent generalising results. The small sample and cross-sectional nature of the assessment timeframes may cause assessments performed at other times during the day to be overlooked. The use of survey-based data may produce bias results, and inability to acquire participant-level data, potentially impacting data quality. Additionally, location limits the generalisation of these results to nurses’ delirium assessments at other facilities. Low CNL participation at the tertiary hospital limits CAM assessments to 5 units, affecting the true assessment compliance and recognition rates. Additionally, only CAM and CAM-ICU tools were utilised in this study. Finally, a recent transition to a new EHR limits the nurses’ familiarity and compliance with necessary documentation.</p>
      </sec>
      <sec>
        <title>Practice Implications</title>
        <p>Clinical implications of this work point to the need for more education and training regarding delirium assessment, interventions, and interprofessional collaboration. Delirium does not occur solely in the morning hours; hence, compliance with delirium assessment per shift and as needed is critical for early detection and intervention. Findings revealed the need for resources to help appropriately assess patients and document this assessment correctly. Assessment documentation is critical for interprofessional teammates managing the care of the patients in future shifts. Future research surrounding the use of the EHR to support compliance and documentation of delirium would provide insight into how nurses can be better supported in an assessment that is known to be difficult, further highlighted in this study.</p>
        <p>Future studies should also explore the clinical practice differences between the two types of units. Here, the High Acuity Units experienced a higher percentage of positive CAM assessments. Interestingly, the use of non-pharmacological interventions and the barrier of personnel shortages were noted within the High Acuity Units compared to the General Units meaning that while High Acuity Units noted staffing barriers, they still used more non-pharmacological interventions than the General Units. Could staffing issues or acuity levels contribute to the differences between the two-unit types?</p>
      </sec>
    </sec>
    <sec>
      <title>CONCLUSION</title>
      <p>The findings of this project call for the need to educate bedside nurses about delirium assessment, focusing on using CAM and non-pharmacological interventions. Additionally, the results provide insight into how nurse leaders can help promote delirium prevention by providing resources to overcome existing barriers. Finally, subsequent projects should focus on ways to optimise CAM use by leveraging technology to improve the identification and prevention of delirium.</p>
      <sec id="coi" sec-type="COI-statement">
        <title>CONFLICT OF INTEREST</title>
        <p>All authors declare that they have conflict of interest.</p>
      </sec>
    </sec>
    <sec sec-type="supplementary-material">
      <title>Supporting information</title>
      <supplementary-material id="attachment-193665">
        <caption>
          <title>Online Supplemental 1</title>
        </caption>
        <media xlink:href="assets/delirium_2024_92219_193665.pdf" mimetype="application" mime-subtype="pdf"/>
      </supplementary-material>
      <supplementary-material id="attachment-192237">
        <caption>
          <title>Supplemental Table 2</title>
        </caption>
        <media xlink:href="assets/delirium_2024_92219_192237.docx" mimetype="application" mime-subtype="vnd.openxmlformats-officedocument.wordprocessingml.document"/>
      </supplementary-material>
    </sec>
  </body>
  <back>
    <ack>
      <title>ACKNOWLEDGMENTS</title>
      <p>Thank you Sharon Hood, Janice Sills, Elizabeth Anderson, Rachel Topper, and Lane Branch for assisting with data collection. We appreciate the PIs of the World Delirium Awareness Day for the opportunity to be a part of the WDAD Point Prevalence study.</p>
    </ack>
    <ref-list>
      <ref id="ref-273592">
        <element-citation publication-type="article-journal">
          <label>1</label>
          <article-title>Delirium in the elderly</article-title>
          <source>Psychiatr Clin North Am</source>
          <person-group person-group-type="author">
            <name>
              <surname>Hshieh</surname>
              <given-names>T.T.</given-names>
            </name>
            <name>
              <surname>Inouye</surname>
              <given-names>S.K.</given-names>
            </name>
            <name>
              <surname>Oh</surname>
              <given-names>E.S.</given-names>
            </name>
          </person-group>
          <date>
            <year>2018</year>
          </date>
          <volume>41</volume>
          <issue>1</issue>
          <fpage>1</fpage>
          <lpage>17</lpage>
          <pub-id pub-id-type="doi">10.1016/j.psc.2017.10.00.1</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.psc.2017.10.00.1.">https://doi.org/10.1016/j.psc.2017.10.00.1.</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273593">
        <element-citation publication-type="article-journal">
          <label>2</label>
          <article-title>Nurses' recognition of hospitalised older patients with delirium and cognitive impairment using the delirium observation Screening scale: A prospective comparison study</article-title>
          <source>Journal of Gerontological Nursing</source>
          <person-group person-group-type="author">
            <name>
              <surname>Hasemann</surname>
              <given-names>Wolfgang</given-names>
            </name>
            <name>
              <surname>Tolson</surname>
              <given-names>Debbie</given-names>
            </name>
            <name>
              <surname>Godwin</surname>
              <given-names>Jon</given-names>
            </name>
            <name>
              <surname>Spirig</surname>
              <given-names>Rebecca</given-names>
            </name>
            <name>
              <surname>Frei</surname>
              <given-names>Irena Anna</given-names>
            </name>
            <name>
              <surname>Kressig</surname>
              <given-names>Reto W.</given-names>
            </name>
          </person-group>
          <date>
            <month>12</month>
            <year>2018</year>
          </date>
          <volume>44</volume>
          <issue>12</issue>
          <fpage>35</fpage>
          <lpage>43</lpage>
          <issn>0098-9134</issn>
          <pub-id pub-id-type="doi">10.3928/00989134-20181018-02</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3928/00989134-20181018-02">https://doi.org/10.3928/00989134-20181018-02</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273594">
        <element-citation publication-type="article-journal">
          <label>3</label>
          <article-title>The economic cost of delirium: A systematic review and quality assessment</article-title>
          <source>Alzheimer's &amp; Dementia</source>
          <person-group person-group-type="author">
            <name>
              <surname>Kinchin</surname>
              <given-names>Irina</given-names>
            </name>
            <name>
              <surname>Mitchell</surname>
              <given-names>Eileen</given-names>
            </name>
            <name>
              <surname>Agar</surname>
              <given-names>Meera</given-names>
            </name>
            <name>
              <surname>Trépel</surname>
              <given-names>Dominic</given-names>
            </name>
          </person-group>
          <date>
            <day>21</day>
            <month>1</month>
            <year>2021</year>
          </date>
          <volume>17</volume>
          <issue>6</issue>
          <fpage>1026</fpage>
          <lpage>1041</lpage>
          <issn>1552-5260</issn>
          <pub-id pub-id-type="doi">10.1002/alz.12262</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1002/alz.12262">https://doi.org/10.1002/alz.12262</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273595">
        <element-citation publication-type="article-journal">
          <label>4</label>
          <article-title>A call to action for delirium research: Meta-analysis and regression of delirium associated mortality</article-title>
          <source>BMC Geriatrics</source>
          <person-group person-group-type="author">
            <name>
              <surname>Thein</surname>
              <given-names>May Zin</given-names>
            </name>
            <name>
              <surname>Pereira</surname>
              <given-names>Jarett V.</given-names>
            </name>
            <name>
              <surname>Nitchingham</surname>
              <given-names>Anita</given-names>
            </name>
            <name>
              <surname>Caplan</surname>
              <given-names>Gideon A.</given-names>
            </name>
          </person-group>
          <date>
            <day>7</day>
            <month>9</month>
            <year>2020</year>
          </date>
          <volume>20</volume>
          <issue>1</issue>
          <fpage>325</fpage>
          <issn>1471-2318</issn>
          <pub-id pub-id-type="doi">10.1186/s12877-020-01723-4</pub-id>
          <pub-id pub-id-type="pmid">32894065</pub-id>
          <pub-id pub-id-type="pmcid">PMC7487610</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12877-020-01723-4">https://doi.org/10.1186/s12877-020-01723-4</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273596">
        <element-citation publication-type="article-journal">
          <label>5</label>
          <article-title>Postoperative delirium screening tools for post-anaesthetic adult patients in non-intensive care units: A systematic review and meta-analysis</article-title>
          <source>Journal of Clinical Nursing</source>
          <person-group person-group-type="author">
            <name>
              <surname>Kim</surname>
              <given-names>Sujeong</given-names>
            </name>
            <name>
              <surname>Choi</surname>
              <given-names>Eunju</given-names>
            </name>
            <name>
              <surname>Jung</surname>
              <given-names>Youngsun</given-names>
            </name>
            <name>
              <surname>Jang</surname>
              <given-names>Insil</given-names>
            </name>
          </person-group>
          <date>
            <year>2023</year>
          </date>
          <volume>32</volume>
          <issue>9-10</issue>
          <fpage>1691</fpage>
          <lpage>1704</lpage>
          <issn>0962-1067</issn>
          <pub-id pub-id-type="doi">10.1111/jocn.16157</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1111/jocn.16157">https://doi.org/10.1111/jocn.16157</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273597">
        <element-citation publication-type="article-journal">
          <label>6</label>
          <article-title>Clarifying confusion: the confusion assessment method. A new method for detection of delirium</article-title>
          <source>Annals of Internal Medicine</source>
          <person-group person-group-type="author">
            <name>
              <surname>Inouye</surname>
              <given-names>Sharon K.</given-names>
            </name>
            <name>
              <surname>van Dyck</surname>
              <given-names>C H</given-names>
            </name>
            <name>
              <surname>Alessi</surname>
              <given-names>C A</given-names>
            </name>
            <name>
              <surname>Balkin</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Siegal</surname>
              <given-names>A P</given-names>
            </name>
            <name>
              <surname>Horwitz</surname>
              <given-names>R I</given-names>
            </name>
          </person-group>
          <date>
            <day>15</day>
            <month>12</month>
            <year>1990</year>
          </date>
          <volume>113</volume>
          <issue>12</issue>
          <fpage>941</fpage>
          <lpage>948</lpage>
          <issn>0003-4819</issn>
          <pub-id pub-id-type="doi">10.7326/0003-4819-113-12-941</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.7326/0003-4819-113-12-941">https://doi.org/10.7326/0003-4819-113-12-941</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273598">
        <element-citation publication-type="article-journal">
          <label>7</label>
          <article-title>Nursing perspectives on the confusion assessment method: a qualitative focus group study</article-title>
          <source>Age Ageing</source>
          <person-group person-group-type="author">
            <name>
              <surname>Wong</surname>
              <given-names>Eric Kai-Chung</given-names>
            </name>
            <name>
              <surname>Lee</surname>
              <given-names>Justin Yusen</given-names>
            </name>
            <name>
              <surname>Surendran</surname>
              <given-names>Anasuiya Sherhee</given-names>
            </name>
            <name>
              <surname>Nair</surname>
              <given-names>Kalpana</given-names>
            </name>
            <name>
              <surname>Della Maestra</surname>
              <given-names>Nancy</given-names>
            </name>
            <name>
              <surname>Migliarini</surname>
              <given-names>Marie</given-names>
            </name>
            <name>
              <surname>St. Onge</surname>
              <given-names>Joye Anne</given-names>
            </name>
            <name>
              <surname>Patterson</surname>
              <given-names>Christopher J</given-names>
            </name>
          </person-group>
          <date>
            <day>25</day>
            <month>7</month>
            <year>2018</year>
          </date>
          <volume>47</volume>
          <issue>6</issue>
          <fpage>880</fpage>
          <lpage>886</lpage>
          <issn>0002-0729</issn>
          <pub-id pub-id-type="doi">10.1093/ageing/afy107</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1093/ageing/afy107">https://doi.org/10.1093/ageing/afy107</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273599">
        <element-citation publication-type="article-journal">
          <label>8</label>
          <article-title>Survey among critical care nurses and physicians about delirium management</article-title>
          <source>Nursing in Critical Care</source>
          <person-group person-group-type="author">
            <name>
              <surname>Nydahl</surname>
              <given-names>Peter</given-names>
            </name>
            <name>
              <surname>Dewes</surname>
              <given-names>Michael</given-names>
            </name>
            <name>
              <surname>Dubb</surname>
              <given-names>Rolf</given-names>
            </name>
            <name>
              <surname>Hermes</surname>
              <given-names>Carsten</given-names>
            </name>
            <name>
              <surname>Kaltwasser</surname>
              <given-names>Arnold</given-names>
            </name>
            <name>
              <surname>Krotsetis</surname>
              <given-names>Susanne</given-names>
            </name>
            <name>
              <surname>von Haken</surname>
              <given-names>Rebecca</given-names>
            </name>
          </person-group>
          <date>
            <year>2018</year>
          </date>
          <volume>23</volume>
          <issue>1</issue>
          <fpage>23</fpage>
          <lpage>29</lpage>
          <issn>1362-1017</issn>
          <pub-id pub-id-type="doi">10.1111/nicc.12299</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1111/nicc.12299">https://doi.org/10.1111/nicc.12299</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273600">
        <element-citation publication-type="article-journal">
          <label>9</label>
          <article-title>“Care left undone” and quality of care during the COVID-19 pandemic: Influential factors and modulating strategies</article-title>
          <source>Enfermería Clínica (English Edition)</source>
          <person-group person-group-type="author">
            <name>
              <surname>Obregón-Gutiérrez</surname>
              <given-names>Noemí</given-names>
            </name>
            <name>
              <surname>Puig-Calsina</surname>
              <given-names>Salut</given-names>
            </name>
            <name>
              <surname>Bonfill-Abella</surname>
              <given-names>Anna</given-names>
            </name>
            <name>
              <surname>Forrellat-González</surname>
              <given-names>Laura</given-names>
            </name>
            <name>
              <surname>Subirana-Casacuberta</surname>
              <given-names>Mireia</given-names>
            </name>
          </person-group>
          <date>
            <month>1</month>
            <year>2022</year>
          </date>
          <volume>32</volume>
          <issue>1</issue>
          <fpage>4</fpage>
          <lpage>11</lpage>
          <issn>2445-1479</issn>
          <pub-id pub-id-type="doi">10.1016/j.enfcle.2021.06.004</pub-id>
          <pub-id pub-id-type="pmid">35094969</pub-id>
          <pub-id pub-id-type="pmcid">PMC8768014</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.enfcle.2021.06.004">https://doi.org/10.1016/j.enfcle.2021.06.004</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273601">
        <element-citation publication-type="article-journal">
          <label>10</label>
          <article-title>The impact of delirium on outcomes for older adults hospitalised with COVID-19</article-title>
          <source>Age Ageing</source>
          <person-group person-group-type="author">
            <name>
              <surname>Marengoni</surname>
              <given-names>Alessandra</given-names>
            </name>
            <name>
              <surname>Zucchelli</surname>
              <given-names>Alberto</given-names>
            </name>
            <name>
              <surname>Grande</surname>
              <given-names>Giulia</given-names>
            </name>
            <name>
              <surname>Fratiglioni</surname>
              <given-names>Laura</given-names>
            </name>
            <name>
              <surname>Rizzuto</surname>
              <given-names>Debora</given-names>
            </name>
          </person-group>
          <date>
            <day>20</day>
            <month>8</month>
            <year>2020</year>
          </date>
          <volume>49</volume>
          <issue>6</issue>
          <fpage>923</fpage>
          <lpage>926</lpage>
          <issn>0002-0729</issn>
          <pub-id pub-id-type="doi">10.1093/ageing/afaa189</pub-id>
          <pub-id pub-id-type="pmid">32821901</pub-id>
          <pub-id pub-id-type="pmcid">PMC7499475</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1093/ageing/afaa189">https://doi.org/10.1093/ageing/afaa189</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273602">
        <element-citation publication-type="article-journal">
          <label>11</label>
          <article-title>Delirium in the Era of COVID-19</article-title>
          <source>Journal of Nursing Care Quality</source>
          <person-group person-group-type="author">
            <name>
              <surname>Byrnes</surname>
              <given-names>Tru</given-names>
            </name>
            <name>
              <surname>Pate</surname>
              <given-names>Kimberly</given-names>
            </name>
            <name>
              <surname>Cochran</surname>
              <given-names>Allyson R.</given-names>
            </name>
            <name>
              <surname>Belin</surname>
              <given-names>Latasia</given-names>
            </name>
          </person-group>
          <date>
            <day>20</day>
            <month>6</month>
            <year>2023</year>
          </date>
          <volume>39</volume>
          <issue>1</issue>
          <fpage>92</fpage>
          <lpage>97</lpage>
          <issn>1057-3631</issn>
          <pub-id pub-id-type="doi">10.1097/ncq.0000000000000732</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1097/ncq.0000000000000732">https://doi.org/10.1097/ncq.0000000000000732</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273603">
        <element-citation publication-type="article-journal">
          <label>12</label>
          <article-title>Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: results of a prospective multi-centre study on World Delirium Awareness Day</article-title>
          <source>BMC Medicine</source>
          <person-group person-group-type="author">
            <collab>Geriatric Medicine Research Collaborative</collab>
          </person-group>
          <date>
            <month>12</month>
            <year>2019</year>
          </date>
          <volume>17</volume>
          <issue>1</issue>
          <fpage>229</fpage>
          <issn>1741-7015</issn>
          <pub-id pub-id-type="doi">10.1186/s12916-019-1458-7</pub-id>
          <pub-id pub-id-type="pmid">31837711</pub-id>
          <pub-id pub-id-type="pmcid">PMC6911703</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12916-019-1458-7">https://doi.org/10.1186/s12916-019-1458-7</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273604">
        <element-citation publication-type="article-journal">
          <label>13</label>
          <article-title>Nurses' recognition of delirium in the hospitalised older adult</article-title>
          <source>Clinical Nurse Specialist</source>
          <person-group person-group-type="author">
            <name>
              <surname>Rice</surname>
              <given-names>Karen L.</given-names>
            </name>
            <name>
              <surname>Bennett</surname>
              <given-names>Marsha</given-names>
            </name>
            <name>
              <surname>Gomez</surname>
              <given-names>Maureen</given-names>
            </name>
            <name>
              <surname>Theall</surname>
              <given-names>Katherine P.</given-names>
            </name>
            <name>
              <surname>Knight</surname>
              <given-names>Michael</given-names>
            </name>
            <name>
              <surname>Foreman</surname>
              <given-names>Marquis D.</given-names>
            </name>
          </person-group>
          <date>
            <month>11</month>
            <year>2011</year>
          </date>
          <volume>25</volume>
          <issue>6</issue>
          <fpage>299</fpage>
          <lpage>311</lpage>
          <issn>0887-6274</issn>
          <pub-id pub-id-type="doi">10.1097/nur.0b013e318234897b</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1097/nur.0b013e318234897b">https://doi.org/10.1097/nur.0b013e318234897b</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273605">
        <element-citation publication-type="article-journal">
          <label>14</label>
          <article-title>Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling</article-title>
          <source>Psychosomatics</source>
          <person-group person-group-type="author">
            <name>
              <surname>McCoy</surname>
              <given-names>Thomas H. Jr.</given-names>
            </name>
            <name>
              <surname>Snapper</surname>
              <given-names>Leslie</given-names>
            </name>
            <name>
              <surname>Stern</surname>
              <given-names>Theodore A.</given-names>
            </name>
            <name>
              <surname>Perlis</surname>
              <given-names>Roy H.</given-names>
            </name>
          </person-group>
          <date>
            <month>9</month>
            <year>2016</year>
          </date>
          <volume>57</volume>
          <issue>5</issue>
          <fpage>480</fpage>
          <lpage>488</lpage>
          <issn>0033-3182</issn>
          <pub-id pub-id-type="doi">10.1016/j.psym.2016.06.001</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.psym.2016.06.001">https://doi.org/10.1016/j.psym.2016.06.001</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273606">
        <element-citation publication-type="article-journal">
          <label>15</label>
          <article-title>“Delirium Day”: a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool</article-title>
          <source>BMC Medicine</source>
          <person-group person-group-type="author">
            <name>
              <surname>Bellelli</surname>
              <given-names>Giuseppe</given-names>
            </name>
            <name>
              <surname>Morandi</surname>
              <given-names>Alessandro</given-names>
            </name>
            <name>
              <surname>Di Santo</surname>
              <given-names>Simona G.</given-names>
            </name>
            <name>
              <surname>Mazzone</surname>
              <given-names>Andrea</given-names>
            </name>
            <name>
              <surname>Cherubini</surname>
              <given-names>Antonio</given-names>
            </name>
            <name>
              <surname>Mossello</surname>
              <given-names>Enrico</given-names>
            </name>
            <name>
              <surname>Bo</surname>
              <given-names>Mario</given-names>
            </name>
            <name>
              <surname>Bianchetti</surname>
              <given-names>Angelo</given-names>
            </name>
            <name>
              <surname>Rozzini</surname>
              <given-names>Renzo</given-names>
            </name>
            <name>
              <surname>Zanetti</surname>
              <given-names>Ermellina</given-names>
            </name>
            <name>
              <surname>Musicco</surname>
              <given-names>Massimo</given-names>
            </name>
            <name>
              <surname>Ferrari</surname>
              <given-names>Alberto</given-names>
            </name>
            <name>
              <surname>Ferrara</surname>
              <given-names>Nicola</given-names>
            </name>
            <name>
              <surname>Trabucchi</surname>
              <given-names>Marco</given-names>
            </name>
          </person-group>
          <date>
            <day>18</day>
            <month>7</month>
            <year>2016</year>
          </date>
          <volume>14</volume>
          <issue>1</issue>
          <fpage>106</fpage>
          <issn>1741-7015</issn>
          <pub-id pub-id-type="doi">10.1186/s12916-016-0649-8</pub-id>
          <pub-id pub-id-type="pmid">27430902</pub-id>
          <pub-id pub-id-type="pmcid">PMC4950237</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12916-016-0649-8">https://doi.org/10.1186/s12916-016-0649-8</ext-link>
        </element-citation>
      </ref>
      <ref id="ref-273607">
        <element-citation publication-type="article-journal">
          <label>16</label>
          <article-title>The 4 ‘A’s test for detecting delirium in acute medical patients: a diagnostic accuracy study</article-title>
          <source>Health Technology Assessment</source>
          <person-group person-group-type="author">
            <name>
              <surname>MacLullich</surname>
              <given-names>Alasdair M J</given-names>
            </name>
            <name>
              <surname>Shenkin</surname>
              <given-names>Susan D</given-names>
            </name>
            <name>
              <surname>Goodacre</surname>
              <given-names>Steve</given-names>
            </name>
            <name>
              <surname>Godfrey</surname>
              <given-names>Mary</given-names>
            </name>
            <name>
              <surname>Hanley</surname>
              <given-names>Janet</given-names>
            </name>
            <name>
              <surname>Stíobhairt</surname>
              <given-names>Antaine</given-names>
            </name>
            <name>
              <surname>Lavender</surname>
              <given-names>Elizabeth</given-names>
            </name>
            <name>
              <surname>Boyd</surname>
              <given-names>Julia</given-names>
            </name>
            <name>
              <surname>Stephen</surname>
              <given-names>Jacqueline</given-names>
            </name>
            <name>
              <surname>Weir</surname>
              <given-names>Christopher</given-names>
            </name>
            <name>
              <surname>MacRaild</surname>
              <given-names>Allan</given-names>
            </name>
            <name>
              <surname>Steven</surname>
              <given-names>Jill</given-names>
            </name>
            <name>
              <surname>Black</surname>
              <given-names>Polly</given-names>
            </name>
            <name>
              <surname>Diernberger</surname>
              <given-names>Katharina</given-names>
            </name>
            <name>
              <surname>Hall</surname>
              <given-names>Peter</given-names>
            </name>
            <name>
              <surname>Tieges</surname>
              <given-names>Zoë</given-names>
            </name>
            <name>
              <surname>Fox</surname>
              <given-names>Christopher</given-names>
            </name>
            <name>
              <surname>Anand</surname>
              <given-names>Atul</given-names>
            </name>
            <name>
              <surname>Young</surname>
              <given-names>John</given-names>
            </name>
            <name>
              <surname>Siddiqi</surname>
              <given-names>Najma</given-names>
            </name>
            <name>
              <surname>Gray</surname>
              <given-names>Alasdair</given-names>
            </name>
          </person-group>
          <date>
            <month>8</month>
            <year>2019</year>
          </date>
          <volume>23</volume>
          <issue>40</issue>
          <fpage>1</fpage>
          <lpage>194</lpage>
          <issn>1366-5278</issn>
          <pub-id pub-id-type="doi">10.3310/hta23400</pub-id>
          <pub-id pub-id-type="pmid">31397263</pub-id>
          <pub-id pub-id-type="pmcid">PMC6709509</pub-id>
          <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3310/hta23400">https://doi.org/10.3310/hta23400</ext-link>
        </element-citation>
      </ref>
    </ref-list>
  </back>
</article>
